HedgehogÐźÅͨ·ÊÇijЩ³ÉÌå¸Éϸ°ûºÍÖ×Áö¸Éϸ°ûµÄ½¹µãÐźÅͨ·֮һ £¬£¬£¬£¬£¬£¬ËüµÄÒì³ £¿£¿£¿£¿£¿Éµ¼Ö¶àÖÖÍËÐÐÐÔ²¡±äºÍ°©Ö¢¡£¡£¡£×Ô1980ÄêHedgehogÐźÅͨ·±»·¢Ã÷ºÍÃüÃûÒÔÀ´ £¬£¬£¬£¬£¬£¬Àú¾ÊýÊ®ÄêµÄ̽Ë÷¡¢Ñо¿ºÍ¿ª·¢ £¬£¬£¬£¬£¬£¬Õë¶ÔHedgehogµÄ°ÐÏò¿¹°©Ò©vismodegibºÍsonidegibÒÑ»®·ÖÓÚ2012ÄêºÍ2015Äê±»ÃÀ¹úFDAÅú×¼¡£¡£¡£Òò´Ë £¬£¬£¬£¬£¬£¬Hedgehogͨ·ÊÇ´Ó»ù´¡Ñо¿×ßÏòÁÙ´²Ó¦ÓõÄÀֳɰ¸ÀýÖ®Ò»¡£¡£¡£
С·Ö×Óµ÷¿Ø»úÖƵÄÑо¿ £¬£¬£¬£¬£¬£¬ÓÈÆäÊÇÃæÏòHedgehogͨ·ÕâÀàÖ÷Òª°ÐµãµÄÑо¿ £¬£¬£¬£¬£¬£¬ÍùÍùÉú³¤³ÉΪͨÏòÁÙ´²Ò©ÎïµÄÔ¿³× £¬£¬£¬£¬£¬£¬Òò´Ë±¸ÊÜÑо¿Ö°Ô±¹Ø×¢¡£¡£¡£´ËÇ° £¬£¬£¬£¬£¬£¬ÓÉÓÚÔÚ¸ÃÁìÓòµÄ¾«²ÊÊÂÇé £¬£¬£¬£¬£¬£¬Öйú¿ÆѧԺ¶¯ÎïÑо¿ËùÑо¿Ô±ÍõÓîºÍÄϼÓÖÝ´óѧ½ÌÊÚAndrew P. McMahonÊÜElife ÔÓÖ¾Ô¼Çë £¬£¬£¬£¬£¬£¬Ëæ±ÊµãÆÀÁË˹̹¸£´óѧ¡¢¹þ·ð´óѧ¡¢Å£½ò´óѧÁìÓòÙÉÐеĹØÓÚHedgehogÐźÅͨ·С·Ö×Óµ÷¿Ø»úÖƵĶàƪÑо¿ÂÛÎÄ¡£¡£¡£
½üÆÚ £¬£¬£¬£¬£¬£¬ÔÙÊÜCellÆìÏ¡¶Ï¸°û»¯Ñ§ÉúÎïѧ¡·£¨Cell Chemical Biology£©ÔÓÖ¾Ô¼Çë £¬£¬£¬£¬£¬£¬ÍõÓîÑо¿×é׫дÁËÌâΪHedgehog Signaling: From Basic Biology to Cancer Therapy µÄ×ÛÊöÎÄÕ¡£¡£¡£¸ÃÎÄϵͳ×ܽáÁ˽üÄêÀ´HedgehogÐźÅͨ·µ÷¿Ø»úÖƵÄÑо¿Ï£Íû £¬£¬£¬£¬£¬£¬ÌØÊâÊÇС·Ö×Óµ÷¿Ø»úÖÆ £¬£¬£¬£¬£¬£¬²¢¾ÍÁìÓòÄÚÖ÷ÒªµÄÒɵãÖ®Ò»——ÄÚԴС·Ö×Óµ÷¿Ø»úÖÆÌá³öÁËÒ»¸öеļÙ˵ģ×Ó¡£¡£¡£×÷Õ߶ԶàÄêÒÔÀ´´ÓһЩС·Ö×ÓÒ©ÎïÔÚÖÎÁÆ°©Ö¢µÄÁÙ´²ÊÔÑéÖÐÈ¡µÃµÄÂÄÀú½Ìѵ¾ÙÐÐÁË×Ü½á £¬£¬£¬£¬£¬£¬¶Ô¸ü¾«×¼µÄÁÙ´²ÖÎÁÆÌá³öÁËÏë·¨ºÍ½¨Òé¡£¡£¡£×îºó £¬£¬£¬£¬£¬£¬×÷Õ߶ÔÁÙ´²ÊÔÑéÖзºÆðÄÍÒ©·´Ó¦µÄÔµ¹ÊÔÓɾÙÐÐÁËÉîÈë̽ÌÖ £¬£¬£¬£¬£¬£¬Ìá³öÏàʶ¾öÕâЩƿ¾±ÎÊÌâµÄ˼Ð÷ £¬£¬£¬£¬£¬£¬ÒÔÆÚÆô·¢ÐÂÒ»´ú¿¹°©Ò©µÄÑз¢ÊÂÇé¡£¡£¡£
¸ÃÎÄÕÂÓÚ3ÔÂ10ÈÕÔÚÏß½ÒÏþÓÚCell Chemical Biology £¬£¬£¬£¬£¬£¬µÚÒ»×÷ÕßΪÍõÓî×éÑо¿ÉúÎ⸶¼Ñ £¬£¬£¬£¬£¬£¬Í¨Ñ¶×÷ÕßΪÍõÓî £¬£¬£¬£¬£¬£¬Ñо¿×éÕÅÓñ¡¢ËﲩÒÔ¼°Andrew P. McMahonÒ²¼ÓÈëÁ˸ÃÎÄÕµÄ׫д¡£¡£¡£ÕâÏîÊÂÇé»ñµÃÁËÖпÆÔº¶¯ÎïËùºÍ¸Éϸ°ûÓëÉúÖ³ÉúÎïѧ¹ú¼ÒÖصãʵÑéÊÒÑо¿Ö°Ô± £¬£¬£¬£¬£¬£¬ÓÈÆäÊÇÖпÆԺԺʿÖÜç÷µÄ¶¦Á¦´ó¾ÙÖ§³ÖºÍ×ÊÖú £¬£¬£¬£¬£¬£¬Í¬Ê±»ñµÃÁ˹ú¼Ò“973”ÏîÄ¿¡¢¹ú¼Ò×ÔÈ»»ù½ðίºÍÖпÆÔºµÄ×ÊÖú¡£¡£¡£